Alexander Fleming and the antibiotic revolution

Alejandro Pérez Capote, Ana Laura Taillacq Suárez, Marcos Manuel Marin Gutiérrez, Bruna Rosario Quevedo Almarales

Texto completo:

PDF

Resumen

The introduction and application of antibiotics has been one of the greatest breakthroughs in medicine to date; the first one used was penicillin by Alexander Fleming in the 20th century.  The main aim of this investigation was to describe the enormous contribution made by Alexander Fleming to medicine, highlighting his outstanding discoveries. A total of 20 bibliographical sources were consulted for this investigation, including 16 scientific journals with a high international impact, 4 books and other sources that were accessed through the main managers of the information network. It was concluded that Alexander Fleming revolutionized the world of medicine, his discoveries of lysozymes and penicillin brought new hope to mankind in fighting certain diseases and treating bacterial infections.

Palabras clave

Alexander Fleming; antibiotics; lysozymes; penicillin

Referencias

Bârsu C. History of Medicine between tradition and modernity. Clujul Med [Internet]. 2017 (cited 2018 Apr 4) ;90(2):243-245. Available from: DOI: 10.15386/cjmed-794; PubMed PMID: 28559713; PubMed Central PMCID: PMC5433581.

Rosen GA History of Public Health. Baltimore: Johns Hopkins University Press Books; 2014.

Cameron DE, Bashor CJ, Collins JJ. A brief history of synthetic biology. NatRev Microbiol [Internet]. 2014 May (cited 2018 Apr 4);12(5):381-90. Available from: DOI: 10.1038/nrmicro3239; PubMed PMID: 24686414.

Adedeji WA. The treasure called antibiotics. Ann Ib Postgrad Med [Internet]. 2016 Dec (cited 2018 Apr 6);14(2):56-57. Available from: PubMed PMID: 28337088; PubMed Central PMCID: PMC5354621.

Macfarlane G. Alexander Fleming: The Man and the Myth. Oxford: Oxford University Press Books; 2010.

Goldsworthy PD, McFarlane AC. Howard Florey, Alexander Fleming and the fairy tale of penicillin. Med J Aust [Internet]. 2002 (cited 2018 Apr 8);176(4):176-8. Available from: PubMed PMID: 11913920.

Ventola CL. The antibiotic resistance crisis: part 1: causes and threats. P T [Internet]. 2015 (cited 2018 Apr 8);40(4):277-83. Available from: PubMed PMID: 25859123; PubMed Central PMCID: PMC4378521.

Alharbi SA, Wainwright M, Alahmadi TA, Salleeh HB, Faden AA, Chinnathambi A.What if Fleming had not discovered penicillin? Saudi J Biol Sci [Internet]. 2014 (cited 2018 Apr 9);21(4):289-93. Available from: DOI: 10.1016/j.sjbs.2013.12.007; PubMed PMID: 25183937; PubMed Central PMCID: PMC4150221.

Dosan S. Penicillin Man: Alexander Fleming and the Antibiotic Revolution. BMJ [Internet]. 2005 (cited 2018 Apr 9); 330(7481): [aprox. 19 p.]. Availalable from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC539899/

Bârsu C. History of Medicine between tradition and modernity. Clujul Med [Internet]. 2017 (cited 2018 Apr 12);90(2):243-245. Available from: DOI: 10.15386/cjmed-794.; PubMed PMID: 28559713; PubMed Central PMCID: PMC5433581.

Tan SY, Tatsumura Y. Alexander Fleming (1881-1955): Discoverer of penicillin. Singapore Med J [Internet]. 2015 (cited 2018 Apr 12);56(7):366-7. Available from: DOI: 10.11622/smedj.2015105. PubMed PMID: 26243971; PubMed Central PMCID: PMC4520913.

Alberts B. A grand challenge in biology. Science [Internet]. 2011 (cited 2018 Apr 12);333(6047):1200. Available from: DOI: 10.1126/science.1213238. PubMed PMID: 21885740.

Ma'ayan A. Complex systems biology. J R Soc Interface [Internet]. 2017 (cited 2018 Apr 12);14(134). Available from: DOI: 10.1098/rsif.2017.0391; PubMed PMID: 28931638; PubMed Central PMCID: PMC5636275.

Lou C, Stanton B, Munsky B. The greatest antibiotic contribution: Alexander Fleming. Nature Biotech [Internet]. 2014 (cited 2018 Apr 13); 30(2): 55-63. Available from: https://www.acs.org/content/acs/en/education/whatischemistry/landmarks/flemingpenicillin.html

Kissick WL. The Life of Sir Alexander Fleming, Discoverer of Penicillin. Yale J Biol Med [Internet].1959 (cited 2018 Apr 13); 32(2): [aprox. 23 p.]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2604061/

Bengtsson B. Alexander Fleming: Pioneer with Antibiotics. Washington: McJohn’s; 2009

Cruickshank R. A Brief Biography of Alexander Fleming. American Journal of Medicine [Internet]. 2016 (cited 2018 Apr 15); 31(3): 12-16. Available from: http://journals.sagepub.com/doi/abs/10.1177/096777200401200105

Brown K. Penicillin Man. The New England Journal of Medicine [Internet]. 2015 (cited 2018 Apr 15); 24(1): 12-14. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433581/

Hare R. The Cambridge Illustrated History of Medicine. Cambridge: Cambridge University Press Books; 2014

Lewine E. Florey and the development of penicillin. Journal of Clinical Investigation [Internet]. 2015 (cited 2018 Apr 16); 14 (2): 4-7. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC539899/

Enlaces refback

  • No hay ningún enlace refback.